Sox5 and Th17 cell differentiation

Sox5 and Th17 cell differentiation

Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1-2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and plays important roles in the development o...

Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3

Stat3 signaling is essential for the induction of RORγt and subsequent Th17 cell differentiation. However, the downstream targets of Stat3 for RORγt expression remain largely unknown. We show here that a novel isoform of Sox5, named Sox5t, is induced in Th17 cells in a Stat3-dependent manner. In vivo, T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resista...

Estradiol Inhibits Th17 Cell Differentiation

Transcriptional regulatory networks in Th17 cell differentiation.

Upon encountering antigen in the context of antigen presenting cells, naïve CD4(+) T cells undergo differentiation into effector T helper (Th) cells, which can secrete high levels of cytokines and other immunomodulators to mediate host defense and tissue inflammation. During the past three years, the immunology field has witnessed an explosion of research advances in the biology of Th17 cells, ...

Dendritic cell MST1 inhibits Th17 differentiation

Although the differentiation of CD4+T cells is widely studied, the mechanisms of antigen-presenting cell-dependent T-cell modulation are unclear. Here, we investigate the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and antifungal inflammation and find that mammalian sterile 20-like kinase 1 (MST1) signalling from DCs negatively regulates IL-17 producing-CD4+T help...